Article
Mismatch repair deficiency in hematological malignancies with microsatellite instability.
Oncogene - 22 Aug 2002
Gu Liya, Cline-Brown Brandee, Zhang Fujian, Qiu Lu, Li Guo-Min
Abstract excerpt
Mutations in human mismatch repair (MMR) genes are the genetic basis for certain types of solid tumors displaying microsatellite instability (MSI). MSI has also been observed in hematological malignancies, but whether these hematological malignancies are associated with MMR deficiency is still unclear. Using both biochemical and genetic approaches, this study analysed MMR proficiency in 11 cell lines derived from...
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