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Article

Mismatch repair gene mutations in renal cell carcinoma.

Cancer biology & therapy - 1 Jan 2000

Leach Fredrick S, Koh Moon, Sharma Kirti, McWilliams Glenn, Talifero-Smith LaTonia, Codd Amanda, Olea Raul, Elbahloul Ossama

Abstract excerpt

We investigated the spectrum and genetic basis for mismatch repair (MMR) deficiency in renal cell carcinoma (RCC) by examining expression of four MMR genes important for hereditary and sporadic carcinogenesis. MMR deficiency was assessed using microsatellite instability (MSI) and genetic analyses of 25 cell lines derived from renal tumors. MMR gene alterations were detected using reverse transcription of RNA...

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Topics

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Share to Base Pair Mismatch
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 3

Share to DNA Repair

Share to Kidney Neoplasms

Share to Neoplasm Proteins

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Source

Identifiers

PMID: 12496483
DOI: 10.4161/cbt.1.5.171

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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