Article
Functional overlap in mismatch repair by human MSH3 and MSH6.
Genetics - 1 Apr 1998
Umar A, Risinger J I, Glaab W E, Tindall K R, Barrett J C, Kunkel T A
Abstract excerpt
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products bind DNA mismatches to initiate strand-specific repair of DNA replication errors. Several studies suggest that a complex of hMSH2 x hMSH6 (hMutSalpha) functions primarily in repair of base x base...
Topics
- Animals
- DNA Repair
- DNA-Binding Proteins
- Humans
- Microsatellite Repeats
- Multidrug Resistance-Associated Proteins
- MutS Homolog 3 Protein
- Mutation
- Nuclear Magnetic Resonance, Biomolecular
- Tumor Cells, Cultured