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Article

Functional overlap in mismatch repair by human MSH3 and MSH6.

Genetics - 1 Apr 1998

Umar A, Risinger J I, Glaab W E, Tindall K R, Barrett J C, Kunkel T A

Abstract excerpt

Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products bind DNA mismatches to initiate strand-specific repair of DNA replication errors. Several studies suggest that a complex of hMSH2 x hMSH6 (hMutSalpha) functions primarily in repair of base x base mismatches or single extra bases, whereas a hMSH2 x hMSH3 complex (hMutSbeta) functions chiefly in repair of...

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Source

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Identifiers

PMID: 9560383
DOI: 10.1093/genetics/148.4.1637
PMCID: PMC1460084

Genes

MSH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional overlap in mismatch repair by human MSH3 and MSH6.PMID 9560383Read ↗

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Human MutY Homolog, a DNA Glycosylase Involved in Base Excision Repair, Physically and Functionally Interacts with Mismatch Repair Proteins Human MutS Homolog 2/Human MutS Homolog 6Semantic proximity Read ↗

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSαSemantic proximity Read ↗

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human DiseasesSemantic proximity Read ↗

Mismatch repair deficiency associated with overexpression of the <i>MSH3</i> geneSemantic proximity Read ↗

MSH3 deficiency is not sufficient for a mutator phenotype in Chinese hamster ovary cells.Semantic proximity Read ↗

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The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.Semantic proximity Read ↗

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