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Article

Oxidative stress inactivates the human DNA mismatch repair system

1 Jul 2002

Abstract excerpt

In the human DNA mismatch repair (MMR) system, hMSH2 forms the hMutSalpha and hMutSbeta complexes with hMSH6 and hMSH3, respectively, whereas hMLH1 and hPMS2 form the hMutLalpha heterodimer. These complexes, together with other components in the MMR system, correct single-base mismatches and small insertion/deletion loops that occur during DNA replication. Microsatellite instability (MSI) occurs when the loops in...

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PMID: 12055083
DOI: 10.1152/ajpcell.00422.2001

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