Article
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2003
Blanc-Brude Olivier P, Mesri Mehdi, Wall Nathan R, Plescia Janet, Dohi Takehiko, Altieri Dario C
Abstract excerpt
PURPOSE: Molecular antagonists of the inhibitor of apoptosis protein survivin have shown promise as novel anticancer strategies for triggering tumor cell apoptosis, dysregulating mitotic progression, and inhibiting tumor growth in preclinical models. However, how survivin couples to the cell death machinery has remained elusive, and the relevant cellular targets of survivin antagonists have not been completely...
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