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The role of TP53 in acute myeloid leukemia: Challenges and opportunities

8 Aug 2019

Abstract excerpt

The tumor suppressor gene TP53 is one of the most frequently mutated genes in human cancer. The central role of the TP53 protein in several fundamental processes such as cancer, aging, senescence, and DNA repair has ensured enormous attention. However, the role of TP53 in acute myeloid leukemia (AML) is enigmatic. Unlike many other human cancers, a vast majority of AMLs display no genomic TP53 alterations. There...

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PMID: 31393631
DOI: 10.1002/gcc.22796

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