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Article

Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.

Blood - 10 Aug 2017

Prokocimer Miron, Molchadsky Alina, Rotter Varda

Abstract excerpt

The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis necessitate therapeutic improvement. Current advances in AML research yield important insights regarding AML genetic, epigenetic, evolutional, and clinical diversity, all in which dysfunctional p53 plays a key role. As p53 is central to hematopoietic stem cell functions, its aberrations affect AML evolution, biology, and therapy...

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Identifiers

PMID: 28607134
DOI: 10.1182/blood-2017-02-763086
PMCID: PMC5659817

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