Article

Clinical and Molecular Characterization of p53-Mutated Acute Myeloid Leukemia

2015-12-03

Abstract excerpt

Abstract P53 is a multifunctional tumor suppressor protein encoded by the TP53 gene, located on the short arm of chromosome 17. Among its functions, it plays a role in maintaining genomic stability by reacting to DNA damage, activating DNA repair programs, and triggering cell cycle arrest. Over half of human malignancies contain mutations or deletions in TP53 that compromise its function. Mutations in TP53 have be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da09f1a5-e237-5f77-b128-a4ebeb77b987
DOI: 10.1182/blood.v126.23.564.564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical and Molecular Characterization of p53-Mutated Acute Myeloid LeukemiaDOI 10.1182/blood.v126.23.564.564Read

What have we learned about TP53-mutated acute myeloid leukemia?Semantic proximity Read

<i>TP53</i> mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomesSemantic proximity Read

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation.Semantic proximity Read

TP53 Mutations in Acute Myeloid Leukemia: Still a Daunting Challenge?Semantic proximity Read

Clinical and molecular characteristics of acute myeloid leukemia and the dismal prognosis of TP53 mutations in a real-world setting.Semantic proximity Read

Evaluating targeted therapies in older patients with TP53-mutated AML.Semantic proximity Read

Breaking the guardian of the genome: TP53 dysfunction in myeloid neoplasms.Semantic proximity Read

Current State and Future Prospects of Diagnosis and Management of TP53-Mutated Myeloid Neoplasms.Semantic proximity Read

The role of TP53 in acute myeloid leukemia: Challenges and opportunitiesSemantic proximity Read

Clinical characteristics and overall survival among acute myeloid leukemia patients with TP53 gene mutation or chromosome 17p deletion.Semantic proximity Read

[Advances in the Treatment of Acute Myeloid Leukemia with TP53 Mutations-Review].Semantic proximity Read

Molecular characterization of AML-MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC-defining criteria, TP53 allelic state, or TP53 variant allele frequency.Semantic proximity Read