Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent.

Abstract excerpt

Unlike normal huntingtin (htt) which is located predominantly in the cytoplasm, mutant htt is also found in the nucleus of affected neurons. Nuclear localization of toxic polyglutamine-containing proteins has been postulated to be necessary for the pathogenesis of triplet repeat disorders. However, little is known about the mechanism by which mutant htt enters the nucleus. We have recently reported exclusive...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Active Transport, Cell Nucleus
• Share to Cell Compartmentation
• Share to Coculture Techniques