Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression.

Journal of cell science - 15 Mar 2005

Iyer Vandana, Pumiglia Kevin, DiPersio C Michael

Abstract excerpt

Matrix metalloproteinases facilitate cell migration and tumor invasion through their ability to proteolyse the extracellular matrix. The laminin-binding integrin alpha3beta1 is expressed at high levels in squamous cell carcinomas and in normal keratinocytes during cutaneous wound healing. We showed previously that alpha3beta1 is required for MMP-9/gelatinase B secretion in immortalized mouse keratinocytes (MK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Butadienes
Share to Fibronectins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrins

Share to Matrix Metalloproteinase 9

Share to Nitriles

Share to Vitronectin

Share to Wound Healing

Source

Identifiers

PMID: 15728252
DOI: 10.1242/jcs.01708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression.PMID 15728252Read ↗

Roles for epithelial integrin α3β1 in regulation of the microenvironment during normal and pathological tissue remodelingSemantic proximity Read ↗

Regulation of fibulin-2 gene expression by integrin α3β1 contributes to the invasive phenotype of transformed keratinocytes.Semantic proximity Read ↗

Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytesSemantic proximity Read ↗

Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling PathwaySemantic proximity Read ↗

Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasionSemantic proximity Read ↗

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.Semantic proximity Read ↗

Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.Semantic proximity Read ↗

Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells.Semantic proximity Read ↗

Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cellsSemantic proximity Read ↗

Regulation of Extracellular Matrix Remodeling following Transforming Growth Factor-β1/Epidermal Growth Factor-Stimulated Epithelial-Mesenchymal Transition in Human Premalignant KeratinocytesSemantic proximity Read ↗

Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.Semantic proximity Read ↗

MT1-MMP controls human mesenchymal stem cell trafficking and differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.