Article
Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression.
Journal of cell science - 15 Mar 2005
Iyer Vandana, Pumiglia Kevin, DiPersio C Michael
Abstract excerpt
Matrix metalloproteinases facilitate cell migration and tumor invasion through their ability to proteolyse the extracellular matrix. The laminin-binding integrin alpha3beta1 is expressed at high levels in squamous cell carcinomas and in normal keratinocytes during cutaneous wound healing. We showed previously that alpha3beta1 is required for MMP-9/gelatinase B secretion in immortalized mouse keratinocytes (MK...
Topics
- Adenoviridae
- Animals
- Blotting, Western
- Butadienes
- Cell Line
- Cell Movement
- Extracellular Matrix
- Fibronectins
- Humans
- Integrin alpha3beta1
- Integrins
- Keratinocytes
- MAP Kinase Signaling System
- Matrix Metalloproteinase 9