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Article

Selective deficits in the expression of striatal‐enriched mRNAs in Huntington's disease

9 Jan 2006

Abstract excerpt

We have identified and cataloged 54 genes that exhibit predominant expression in the striatum. Our hypothesis is that such mRNA molecules are likely to encode proteins that are preferentially associated with particular physiological processes intrinsic to striatal neurons, and therefore might contribute to the regional specificity of neurodegeneration observed in striatal disorders such as Huntington's disease...

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PMID: 16405510
DOI: 10.1111/j.1471-4159.2005.03588.x

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