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Article

Simultaneous genotyping of single nucleotide polymorphisms in the IL-1 gene complex by multiplex polymerase chain reaction-restriction fragment length polymorphism.

Journal of immunological methods - 15 Sept 2002

Tseng Li-Hui, Chen Pei-Jer, Lin Ming-Tseh, Singleton Kentner, Martin Emily G, Yen Ai-Hsin, Martin Paul J, Hansen John A

Abstract excerpt

The interleukin-1 (IL-1) gene complex consists of the IL-1alpha, IL-1beta and IL-1 receptor antagonist genes. Single-nucleotide polymorphisms (SNP) in all three genes have been associated with human diseases. In this study, primers containing mismatches at 1-3 nucleotide positions were designed to incorporate a restriction site for endonuclease AlwNI or XcmI in the presence of allele-specific nucleotides at the...

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PMID: 12165436
DOI: 10.1016/s0022-1759(02)00165-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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