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Article

Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism.

Nature protocols - 1 Jan 2007

Ota Masao, Fukushima Hirofumi, Kulski Jerzy K, Inoko Hidetoshi

Abstract excerpt

Accurate analysis of DNA sequence variation in not only humans and animals but also other organisms has played a significant role in expanding our knowledge about genetic variety and diversity in a number of different biological areas. The search for an understanding of the causes of genetic variants and mutations has resulted in the development of a simple laboratory technique, known as the polymerase chain...

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PMID: 18007620
DOI: 10.1038/nprot.2007.407

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