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Article

Changes of the secondary structure of the 5' end of the Sindbis virus genome inhibit virus growth in mosquito cells and lead to accumulation of adaptive mutations.

Journal of virology - 1 May 2004

Fayzulin Rafik, Frolov Ilya

Abstract excerpt

Both the 5' end of the Sindbis virus (SIN) genome and its complement in the 3' end of the minus-strand RNA synthesized during virus replication serve as parts of the promoters recognized by the enzymes that comprise the replication complex (RdRp). In addition to the 5' untranslated region (UTR), which was shown to be critical for the initiation of replication, another 5' sequence element, the 51-nucleotide (nt)...

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Identifiers

PMID: 15113874
DOI: 10.1128/jvi.78.10.4953-4964.2004
PMCID: PMC400360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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