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Article

Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication.

Nature genetics - 1 Sept 2002

Kitami Toshimori, Nadeau Joseph H

Abstract excerpt

During evolution different genes evolve at unequal rates, reflecting the varying functional constraints on phenotype. An important contributor to this variation is genetic buffering, which reduces the potential detrimental effects of mutations. We studied whether gene duplication and redundant metabolic networks affect genetic buffering by comparing the evolutionary rate of 242 human and mouse orthologous genes...

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PMID: 12161750
DOI: 10.1038/ng945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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