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Article

Evolutionary constraint and adaptation in the metabolic network of Drosophila.

Molecular biology and evolution - 1 Dec 2008

Greenberg Anthony J, Stockwell Sarah R, Clark Andrew G

Abstract excerpt

Organisms must carefully control their metabolism in order to survive. On the other hand, enzymes must adapt in response to evolutionary pressures on the pathways in which they are imbedded. Taking advantage of the newly available whole-genome sequences of 12 Drosophila species, we examined how protein function and metabolic network architecture influence rates of enzyme evolution. We found that despite high...

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Identifiers

PMID: 18799713
DOI: 10.1093/molbev/msn205
PMCID: PMC2721553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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