Article

Influence of pathway topology and functional class on the molecular evolution of human metabolic genes

2018-04-05

Abstract excerpt

Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of purifying selection can be measured. This has made possible to know where, in the metabolic network, adaptive selection has acted and where purifying selection is more...

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Literature Corpus work: 391baf05-616b-5811-8eb6-c1d0a5a25cdf
DOI: 10.1101/292714

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