Article
Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13.
The Journal of clinical endocrinology and metabolism - 1 Aug 2002
Carn Gwenaelle, Koller Daniel L, Peacock Munro, Hui Siu L, Evans Wayne E, Conneally P Michael, Johnston C Conrad, Foroud Tatiana, Econs Michael J
Abstract excerpt
A major determinant of the risk of osteoporosis is peak bone mineral density (BMD), which has been shown to have substantial heritability. The genes for 3 BMD-related phenotypes (autosomal dominant high bone mass, autosomal recessive osteoporosis-pseudoglioma, and autosomal recessives osteopetrosis) are all in the chromosome 11q12-13 region. We reported linkage of peak BMD in a large sample of healthy...
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