Article
Isolation and structural identification of a direct-acting mutagen derived from N-nitroso-N-methylpentylamine and Fenton's reagent with copper ion.
Bioorganic & medicinal chemistry - 15 Sept 2011
Miura Motofumi, Inami Keiko, Yoshida Masafumi, Yamaguchi Kentaro, Mashino Tadahiko, Mochizuki Masataka
Abstract excerpt
N-Nitrosodialkylamines show their mutagenicity by forming α-hydroxynitrosamines in the presence of rat S9 mix in the Ames assay. The hydroxyl radical derived from Fe(2+)-H(2)O(2) (Fenton's reagent) with Cu(2+) activates N-nitrosamines, with an alkyl chain longer than a propyl constituent, to a direct-acting mutagen. The reactivity of Fe(2+)-Cu(2+)-H(2)O(2) on nitrosamines in relation to their metabolic activation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.