Article
CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jul 2013
Zanoni Thalita Boldrin, Lizier Thiago M, Assis Marilda das Dores, Zanoni Maria Valnice B, de Oliveira Danielle Palma
Abstract excerpt
This work describes the mutagenic response of Sudan III, an adulterant food dye, using Salmonella typhimurium assay and the generation of hazardous aromatic amines after different oxidation methods of this azo dye. For that, we used metabolic activation by S9, catalytic oxidation by ironporphyrin and electrochemistry oxidation in order to simulate endogenous oxidation conditions. The oxidation reactions promoted...
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