Article
What is the role of HLA-B27 in spondyloarthropathies?
Autoimmunity reviews - 1 Jun 2011
Chatzikyriakidou Anthoula, Voulgari Paraskevi V, Drosos Alexandros A
Abstract excerpt
HLA-B27 (Human Leukocyte Antigen-B27) accounts approximately for the one third of the overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes have been reported all over the world with a decreasing north-south gradient of its frequency, which is reverse to that of endemic malaria. In an attempt to explain the possible role of HLA-B27 in SpAs pathogenesis, several theories have...
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