Article
HLA-B27 and immunogenetics of spondyloarthropathies.
Current opinion in rheumatology - 1 Jul 2000
Alvarez I, López de Castro J A
Abstract excerpt
The arthritogenic peptide hypothesis has inspired research aimed at defining the peptide-presenting properties of HLA-B27 subtypes and their relation to ankylosing spondylitis. Various studies have shed new light on the influence of HLA-B27 polymorphism in modulating peptide binding and T-cell antigen presentation. Moreover, multiple factors along the antigen processing-loading pathway, including tapasin,...
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