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Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy

18 Jan 2021

Abstract excerpt

Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the mechanisms underlying disease pathogenesis are elusive. Over the years, three hypotheses have been proposed to explain HLA-B27 and disease association: 1) HLA...

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PMID: 33537028
DOI: 10.3389/fimmu.2020.586494

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