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Article

Accelerated Progression of Asbestos-Induced Mesotheliomas in Heterozygous p53+/- Mice

1 Aug 2002

Abstract excerpt

Asbestos fibers produce diffuse malignant mesotheliomas in chronic rodent inhalation assays or after direct intrapleural or intraperitoneal injection. In vitro models have provided evidence that asbestos fibers are genotoxic carcinogens that can directly or indirectly generate reactive oxygen- and nitrogen-derived species that cause DNA damage. Heterozygous p53+/- mice show an increased incidence and reduced...

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PMID: 12151629
DOI: 10.1093/toxsci/68.2.331

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