Article
The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models.
BMC cancer - 8 Aug 2020
Ramelow Julian, Brooks Christopher D, Gao Li, Almiman Abeer A, Williams Terence M, Villalona-Calero Miguel A, Duan Wenrui
Abstract excerpt
BACKGROUND: Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor protein p53 are among the most common alterations in human lung cancers. METHODS: Previously, we...
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