Article
The macrolide binding site on the bacterial ribosome.
Current drug targets. Infectious disorders - 1 Mar 2002
Poehlsgaard Jacob, Douthwaite Stephen
Abstract excerpt
Macrolides are a diverse group of antimicrobials that are widely prescribed in clinical and veterinary medicine. Macrolides inhibit bacterial growth by interacting with the large (50S) subunit of the ribosome and thereby blocking protein synthesis. The liberal application of macrolides and the me...
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