Article
A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth.
Genetics - 1 Jun 2005
Laviolette Matthew J, Nunes Paula, Peyre Jean-Baptiste, Aigaki Toshiro, Stewart Bryan A
Abstract excerpt
The Drosophila larval neuromuscular system serves as a valuable model for studying the genes required for synaptic development and function. N-Ethylmaleimide sensitive factor (NSF) is a molecule known to be important in vesicular trafficking but neural expression of a dominant negative form of NSF2 induces an unexpected overgrowth of the Drosophila larval neuromuscular synapse. We have taken a genetic approach to...
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