Article
V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.
Blood - 15 Aug 2002
Kröber Alexander, Seiler Till, Benner Axel, Bullinger Lars, Brückle Elsbeth, Lichter Peter, Döhner Hartmut, Stilgenbauer Stephan
Abstract excerpt
In chronic lymphocytic leukemia (CLL), biologic risk factors such as immunoglobulin variable heavy chain gene (V(H)) mutation status, CD38 expression level, and genomic aberrations have recently been identified, but the relative prognostic impact of the individual parameters is unknown. In the current study, we analyzed V(H) mutation status by polymerase chain reaction and sequencing (n = 300), genomic...
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