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Article

Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia

24 Oct 2011

Abstract excerpt

There is remarkable heterogeneity in the clinical course and biological characteristics of patient subgroups with chronic lymphocytic leukemia (CLL). Mutations of key tumor suppressors (ATM, miR-15a/16-1 and TP53) have been identified in CLL, and these aberrations are important "drivers" of the disease and some of its clinical characteristics. While some mutations are associated with poor outcome [particularly...

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PMID: 22023519
DOI: 10.3109/10428194.2011.631638

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