Article
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.
Blood - 29 Jan 2015
Jones Emma, Pasricha Sant-Rayn, Allen Angela, Evans Patricia, Fisher Chris A, Wray Katherine, Premawardhena Anuja, Bandara Dyananda, Perera Ashok, Webster Craig, Sturges Pamela, Olivieri Nancy F, St Pierre Timothy, Armitage Andrew E, Porter John B, Weatherall David J, Drakesmith Hal
Abstract excerpt
Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage on hepcidin is also unknown, but it could be relevant for iron supplementation programs aimed at...
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