Article
Interaction of malaria with a common form of severe thalassemia in an Asian population.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
O'Donnell A, Premawardhena A, Arambepola M, Samaranayake R, Allen S J, Peto T E A, Fisher C A, Cook J, Corran P H, Olivieri Nancy F, Weatherall D J
Abstract excerpt
In many Asian populations, the commonest form of severe thalassemia results from the coinheritance of HbE and beta thalassemia. The management of this disease is particularly difficult because of its extreme clinical diversity; although some genetic and adaptive factors have been identified as phenotypic modifiers, the reasons remain unclear. Because the role of the environment in the course of severe thalassemia...
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