Article
Experimental models to study molecular mechanisms underlying intestinal inflammation.
Annals of the New York Academy of Sciences - 17 Nov 1998
Elson C O, Cong Y, Brandwein S, Weaver C T, McCabe R P, Mähler M, Sundberg J P, Leiter E H
Abstract excerpt
Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that a...
Topics
- Animals
- Cytokines
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Immunity, Mucosal
- Inflammation
- Inflammatory Bowel Diseases
- Major Histocompatibility Complex
- Mice
- Mice, Inbred Strains
- Receptors, Cytokine
- T-Lymphocytes