Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.

doi:10.1038/gene.2015.41

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Article

Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.

Genes and immunity - 1 Jan 2000

Beatty S C, Yuki K E, Eva M M, Dauphinee S, Larivière L, Vidal S M, Malo D

Abstract excerpt

The outcome of infection with Salmonella Typhimurium in mouse models of human typhoid fever is dependent upon a coordinated complex immune response. A panel of recombinant congenic strains (RCS) derived from reciprocal backcross of A/J and C57BL/6J mice was screened for their susceptibility to Salmonella infection and two susceptibility loci, Ity4 (Immunity to Typhimurium locus 4) and Ity5, were identified. We...

Topics

Animals
CD40 Antigens
Cation Transport Proteins
Crosses, Genetic
Disease Models, Animal
Gene Expression Profiling
Genetic Predisposition to Disease
Immunoglobulins
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
Neutrophil Activation
Salmonella Infections, Animal

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PMID: 26562079
DOI: 10.1038/gene.2015.41

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