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Article

Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.

Endocrinology - 1 Jul 2014

Prabhu Yogikala, Blanco Elias H, Liu Ming, Peinado Juan R, Wheeler Matthew C, Gekakis Nicholas, Arvan Peter, Lindberg Iris

Abstract excerpt

Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of...

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Identifiers

PMID: 24828610
DOI: 10.1210/en.2013-1985
PMCID: PMC4060179

Genes

PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24828610-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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