Article
beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease.
Pharmacogenetics - 1 Jul 2002
Büscher Rainer, Eilmes Katrin Jennifer, Grasemann Hartmut, Torres Brian, Knauer Nicola, Sroka Karin, Insel Paul A, Ratjen Felix
Abstract excerpt
The cystic fibrosis membrane conductance regulator can be activated through beta2-adrenoceptor (beta2AR) stimulation. We tested the hypothesis that coding sequence polymorphisms in the beta2AR gene contribute to the disease state in patients with cystic fibrosis. The Arg16Gly, Gln27Glu, and Thr164Ile beta2AR polymorphisms were studied by specific polymerase chain reaction and restriction fragment length...
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