Article
Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD.
Respirology (Carlton, Vic.) - 1 May 2008
Umeda Nobuaki, Yoshikawa Takahiro, Kanazawa Hiroshi, Hirata Kazuto, Fujimoto Shigeo
Abstract excerpt
BACKGROUND AND OBJECTIVE: Recently, there has been interest in interactions of beta(2) adrenergic receptors (beta(2)-AR) and muscarinic acetylcholine receptors (mAChR), which share intracellular signal transduction systems. The aim of the present study was to investigate whether bronchodilator response to tiotropium is influenced by beta(2)-AR genotype in patients with COPD who show poor responsiveness to inhaled...
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