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Article

Galnt1 Is Required for Normal Heart Valve Development and Cardiac Function

23 Jan 2015

Abstract excerpt

Congenital heart valve defects in humans occur in approximately 2% of live births and are a major source of compromised cardiac function. In this study we demonstrate that normal heart valve development and cardiac function are dependent upon Galnt1, the gene that encodes a member of the family of glycosyltransferases (GalNAc-Ts) responsible for the initiation of mucin-type O-glycosylation. In the adult mouse,...

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PMID: 25615642
DOI: 10.1371/journal.pone.0115861

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