Article
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.
Molecular psychiatry - 1 Jan 2002
Sklar P, Gabriel S B, McInnis M G, Bennett P, Lim Y -M, Tsan G, Schaffner S, Kirov G, Jones I, Owen M, Craddock N, DePaulo J R, Lander E S
Abstract excerpt
Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the...
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