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Article

Smad4 is Essential for Down-regulation of E-cadherin Induced by TGF- in Pancreatic Cancer Cell Line PANC-1

19 Dec 2006

Abstract excerpt

Smad4 is a tumour suppressor gene frequently deleted in pancreatic cancer. To investigate the roles of Smad4 deficiency in invasive and matastatic capabilities of pancreatic cancer, we examined the effects of Smad4 deficiency on regulation of the invasion suppressor E-cadherin in pancreatic cancer cell line PANC-1. TGF-beta decreased expression of E-cadherin and beta-catenin proteins at the plasma membrane,...

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PMID: 17301079
DOI: 10.1093/jb/mvm039

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Smad4 is Essential for Down-regulation of E-cadherin Induced by TGF- in Pancreatic Cancer Cell Line PANC-1PMID 17301079Read ↗

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