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Article

Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.

American journal of physiology. Renal physiology - 15 Dec 2014

Park Jung Tak, Kato Mitsuo, Lanting Linda, Castro Nancy, Nam Bo Young, Wang Mei, Kang Shin-Wook, Natarajan Rama

Abstract excerpt

Accumulation of mesangial extracellular matrix (ECM) proteins such as collagen type 1-α2 (Col1a2) and collagen type 4-α1 (Col4a1) is a key feature of diabetic nephropathy (DN). Transforming growth factor (TGF)-β1 plays important roles in ECM accumulation in DN, and evidence shows a mediatory role for microRNAs. In the present study, we found that microRNA let-7 family members (let-7b/c/d/g/i) were downregulated...

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Identifiers

PMID: 25354942
DOI: 10.1152/ajprenal.00458.2014
PMCID: PMC4269695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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