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Article

Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway.

Cancer letters - 28 Oct 2006

Qiao Jingbo, Kang Junghee, Ko Tien C, Evers B Mark, Chung Dai H

Abstract excerpt

Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis; dysregulation of the TGF-beta/Smad pathway has been noted in cancer cells. Therefore, we sought...

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Identifiers

PMID: 16412560
DOI: 10.1016/j.canlet.2005.11.007
PMCID: PMC2614268

Genes

GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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