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Article

Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors.

Journal of cellular biochemistry - 15 Oct 2004

Heegaard Anne-Marie, Xie Zhongjian, Young Marian Frances, Nielsen Karina Lishmann

Abstract excerpt

Biglycan is a small leucine-rich proteoglycan which is localized in the extracellular matrix of bone and other specialized connective tissues. Both biglycan mRNA and protein are up-regulated by transforming growth factor-beta(1) (TGF-beta(1)) and biglycan appears to influence TGF-beta(1) activity. In this study, we have investigated the mechanism by which TGF-beta(1), TGF-beta(2) and TGF-beta(3) stimulate...

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PMID: 15372625
DOI: 10.1002/jcb.20189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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