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Article

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells.

Molecular carcinogenesis - 1 Sept 1999

Dai J L, Schutte M, Bansal R K, Wilentz R E, Sugar A Y, Kern S E

Abstract excerpt

DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-beta (TGFbeta)-suppressiv...

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Source

Identifiers

PMID: 10487520
DOI: 10.1002/(sici)1098-2744(199909)26:1<37::aid-mc5>3.0.co;2-6

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10487520-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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