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Article

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5.

Journal of cardiovascular electrophysiology - 1 Jul 2002

Wakimoto Hiroko, Kasahara Hideko, Maguire Colin T, Izumo Seigo, Berul Charles I

Abstract excerpt

INTRODUCTION: Nkx2.5 is a conserved homeodomain (HD) containing transcription factor essential for early cardiac development. We generated a DNA nonbinding missense mutation, I183P in the HD, similar to the missense HD mutation found in patients. Transgenic mice expressing this mutation under beta-MHC promoter [beta-MHC(I183P)] showed a postnatal lethal phenotype with heart failure. In contrast, mice expressing...

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PMID: 12139292
DOI: 10.1046/j.1540-8167.2002.00682.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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