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Article

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.

Genesis (New York, N.Y. : 2000) - 1 Nov 2003

Wakimoto Hiroko, Kasahara Hideko, Maguire Colin T, Moskowitz Ivan P G, Izumo Seigo, Berul Charles I

Abstract excerpt

Nkx2.5 is a conserved homeodomain (HD) containing a transcription factor essential for early cardiac development. We generated several mutations modeling some patients with congenital heart disease. Transgenic mice (tg) expressing the wildtype Nkx2.5 under beta-myosin heavy chain (MHC) promoter died during the embryonic stage. However, tg mice expressing this mutation under beta-MHC promoter (beta-MHC-TG(I183P)),...

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Identifiers

PMID: 14595838
DOI: 10.1002/gene.10236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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