Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.

The Journal of clinical investigation - 1 Jul 2001

Kasahara H, Wakimoto H, Liu M, Maguire C T, Converso K L, Shioi T, Huang W Y, Manning W J, Paul D, Lawitts J, Berul C I, Izumo S

Abstract excerpt

A DNA nonbinding mutant of the NK2 class homeoprotein Nkx2.5 dominantly inhibits cardiogenesis in Xenopus embryos, causing a small heart to develop or blocking heart formation entirely. Recently, ten heterozygous CSX/NKX2.5 homeoprotein mutations were identified in patients with congenital atrioventricular (AV) conduction defects. All four missense mutations identified in the human homeodomain led to markedly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connexin 43
Share to Connexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Echocardiography

Share to Gap Junction alpha-5 Protein

Share to Heart Failure

Share to Homeobox Protein Nkx-2.5

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11457872
DOI: 10.1172/JCI12694
PMCID: PMC203028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.PMID 11457872Read ↗

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5.Semantic proximity Read ↗

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.Semantic proximity Read ↗

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.Semantic proximity Read ↗

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways.Semantic proximity Read ↗

Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.Semantic proximity Read ↗

Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.Semantic proximity Read ↗

Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans.Semantic proximity Read ↗

Congenital heart disease caused by mutations in the transcription factor NKX2-5.Semantic proximity Read ↗

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.Semantic proximity Read ↗

A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation.Semantic proximity Read ↗

Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.Semantic proximity Read ↗

Novel Point Mutation in the Cardiac Transcription Factor CSX/NKX2.5 Associated With Congenital Heart Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.