Article
Molecular basis of scrapie strain glycoform variation.
The Journal of biological chemistry - 27 Sept 2002
Vorberg Ina, Priola Suzette A
Abstract excerpt
Transmissible spongiform encephalopathies (TSE) are characterized by the conversion of a protease-sensitive host glycoprotein, prion protein or PrP-sen, to a protease-resistant form (PrP-res). PrP-res molecules that accumulate in the brain and lymphoreticular system of the host consist of three differentially glycosylated forms. Analysis of the relative amounts of the PrP-res glycoforms has been used to...
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