Article
Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.
Acta biochimica Polonica - 1 Jan 2002
Derebecka Natalia, Hołysz Marcin, Dankowski Rafał, Wierzchowiecki Michał, Trzeciak Wiesław H
Abstract excerpt
Nitric oxide (NO) is synthesised in the vascular endothelium by nitric oxide synthase (NOS3) and is an important factor in the regulation of blood pressure. Impaired synthesis of NO due to mutations in the NOS3 gene is associated with hypertension. To date several allelic variants of the NOS3 gene have been identified and their possible linkage with hypertension investigated. We studied the distribution of...
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