Article
Single-nucleotide polymorphism and mutation identification by the nanogen microelectronic chip technology.
Methods in molecular medicine - 1 Jan 2005
Ferrari Maurizio, Cremonesi Laura, Bonini Pierangelo, Foglieni Barbara, Stenirri Stefania
Abstract excerpt
The present chapter describes a microarray technology developed by Nanogen Inc., for the identification of DNA variations based on the use of microelectronics. The NMW 1000 NanoChip Molecular Biology Workstation allows the active deposition and concentration of charged biotinylated molecules on designated test sites. The DNA at each pad is then hybridized with specific oligonucleotide probes, complementary to...
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