Article
Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance.
Scientific reports - 23 May 2018
Guo Jianping, Gao Yanyan, Wang Yuxuan, Zou Yundong, Du Yan, Luo Cainan, Shi Yamei, Yang Yue, Wu Xinyu, Su Yin, Wu Lijun, Chen Shi, Li Zhanguo
Abstract excerpt
Although rare variant C1Q deficiency was identified as causative risk for systemic lupus erythematosus (SLE), there are limited and inconsistent reports regarding the common polymorphisms of C1Q genes in SLE susceptibility. Furthermore, there are no reports concerning polymorphisms of C1S, C1R, and C1RL and whether they confer susceptibility to SLE. We therefore evaluated 22 SNPs across six C1-complex genes in...
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